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Abstract #19128 Published in IGR 3-1
Short-time application of latanoprost does not stimulate melanogenesis in bovine ocular melanin-containing cells in vitro
Loeffler KU; Sahm M; Spitznas MOphthalmic Research 2001; 33: 102-106
Topical use of latanoprost for glaucoma can lead to an increase in iris and eye lash pigmentation, but the precise mechanism is unclear. To study the possible effect of this drug on ocular melanogenesis, the authors used cultures of bovine iris melanocytes, iris pigment epithelial cells, retinal pigment epithelial cells, and choroidal melanocytes. Latanoprost (at concentrations of 10-8 and 10-6 mol) was applied for three days, and cell numbers as well as melanin content were measured prior to, and ten days after, exposure, and compared to untreated controls. In none of the cell types examined was a significant increase in melanin content or an increase in cell proliferation observed. Additional treatment with the tyrosinase inhibitor α-methyl-p-tyrosine showed no significant effect either. These results support the concept of a rather complex mechanism underlying the increased iris pigmentation after treatment with latanoprost.
Dr K.U. Loeffler, Department of Ophthalmology, University of Bonn, Germany
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)