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Abstract #19131 Published in IGR 3-1
Histological effects in the iris after 3 months of latanoprost therapy: the Mainz 1 study
Pfeiffer N; Grierson I; Goldsmith H; Hochgesand D; Winkgen-Boehres A; Appleton PArchives of Ophthalmology 2001; 119: 191-196
OBJECTIVE: To determine whether three months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma. METHODS: Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for three months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen were obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using two cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67). RESULTS: No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens. CONCLUSIONS: Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.
Dr N. Pfeiffer, Department of Ophthalmology, Mainz University, Langenbeckstrasse 1, 55131 Mainz;,Germany
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
