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Abstract #19138 Published in IGR 3-1
Migraine headache associated with latanoprost
Weston BCArchives of Ophthalmology 2001; 119: 300-301
This is a report of three patients who experienced new onset of migraine headache after taking latanoprost. Two patients had to discontinue the drug. The author explains the migraine by the trigeminovascular theory of pathogenesis. In one case, the patient continued taking latanoprost without further headaches. One case was not rechallenged, and one did agree to rechallenge. The rechallenge was positive. In the latter case, the migraine has not returned. The author suggests that latanoprost may have caused migraine via activation of the trigeminovascular system. Prostaglandin F2α is a vasoactive agent. Hyperemia caused by prostaglandin is thought to be mediated by nitric-oxide release. Latanoprost stimulates the production of endogenous prostaglandins. It is suggested that a small concentration of the drug could be enough to stimulate the trigeminovascular system. Interestingly, headache is a major adverse effect of a similar prostaglandin analogue.
Dr B.C. Weston, Department of Ophthalmology, University of South Alabama, HSB Room 2500, 307, University Boulevard, Mobile, AL 36688, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)