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Abstract #19139 Published in IGR 3-1
Latanoprost-induced side effects and potential mechanisms
Zhai X; Samples JRJournal of Toxicology – Cutaneous and Ocular Toxiclogy 2000; 19: 177-197
The authors have summarized the currently published cases of latanoprost-induced side-effects and have explored the potential mechanisms causing these effects. These side-effects can be related to the multiple receptor-mediated functions demonstrated in vitro and in vivo by latanoprost and/or its cellular analog, which include the roles in vasodynamics, inflammation, melanogenesis, smooth muscle action, and uveoscleral flow. It must be recognized that latanoprost as an effective and valuable therapeutic agent is in general safe in low-risk populations. However, mechanistic understanding of the potential side-effects is rather limited. In particular, clinical trials do not include high-risk patients, and frequently it is these patients who need an additional drug modality to control their glaucoma. Caution and active follow-up are necessary among this group of patients when the use of latanoprost is considered. We are dealing with a relatively new drug, whose mechanism of action is still under active investigation, whose cellular target receptor mediates multiple biological activities, and is intricately linked to the release of other mediators. This mechanistically oriented review suggests that a number of basic pharmacological studies are needed on this compound.
Dr J.R. Samples, Department of Ophthalmology, UOHSU, 3375 S.W. Terwilliger Boulevard, Portland, OR 97201, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)