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Abstract #19193 Published in IGR 3-1
Influence of tear film of postoperative 5-fluorouracil and intraoperative mitomycin C in glaucoma filtration surgery
Li J; Pang LChinese Journal of Ophthalmology 2001; 37: 43
OBJECTIVE: To investigate the changes in tear film functions due to the use of postoperative 5-fluorouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery. METHODS: Seventy-one eyes of 71 refractory glaucoma patients were followed up after filtration surgery. They were divided into three groups: the 5-Fu and MMC groups consisted of 24 and 17 eyes, respectively; the remaining 30 eyes that underwent surgery without the use of antimetabolic agents formed the control group. The symptoms observed included ocular foreign body sensation, dryness, photophobia, itching, and discharge. The criteria available were conjunctival congestion, fluorescein and rose bengal staining on the cornea and conjunctiva, break-up time of the tear film, and Schirmer's test. RESULTS: Ocular signs and symptoms were manifest and tear film functions were significantly decreased in the 5-Fu group (p < 0.05). No significant difference between the MMC and control groups was seen, except that the dry feeling was significantly more intensive in the MMC group (p < 0.05). CONCLUSIONS: The postoperative use of 5-Fu after glaucoma filtration surgery apparently leads to tear film abnormalities. LA: Chinese
Dr J. Li, Department of Ophthalmology, First School of Clinical Medicine, Beijing Medical University, Beijing 100034, China
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)