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Abstract #19246 Published in IGR 9-3
Hypotensive effect of profilin on rabbit intraocular pressure
Morales M; Gomez-Cabrero A; Peral A; Gasull X; Pintor JEuropean Journal of Pharmacology 2007; 567: 145-148
Ocular hypertension is a negative process that occurs within the eye and is the main risk factor to develop glaucoma, a progressive loss of vision due to degeneration of retinal ganglion cells. The protein transduction technique allows a cargo to cross biological membranes. Using this technique we have previously shown that a membrane permeable version of profilin I (PTD4-profilin) increased aqueous humour outflow facility. Here we have investigated if a topical application of PTD4-profilin was able to modify intraocular pressure in rabbits. 10 μM PTD4-profilin (10 μL), reduced intraocular pressure by 20% compared to the control vehicle, this value being in the range of other commercial drugs, which produced intraocular pressure reductions between 18 and 35%. The mean-time effect for PTD4-profilin was 6.8 h and was also in the same range as commercial products that provided values between 4.3 and 5.5 h. According to the results presented here we propose PTD4-profilin as a new approach for the treatment of ocular hypertension and PTD4 as a new strategy to facilitate the penetration of molecules into the eye.
Dr. J. Pintor, Department of Biochemistry, E.U. Optica, University Complutense, c/Arcos de Jalon s/n, E-28037 Madrid, Spain. jpintor@vet.ucm.es
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)