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1 General aspects (0)   1.1 Epidemiology (4)   1.2 Population genetics (1)   1.3 Pathogenesis (1)   1.4 Quality of life (7)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (11) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (13)   2.3 Sclera (4)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (8)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (1)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (3)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (2)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (3)   2.9 Ciliary body (3)   2.10 Lens (1)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (24)   2.14 Optic disc (18)   2.15 Optic nerve (4)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (5)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (12)     3.4.2 Gene studies (10)   3.5 Molecular biology incl. 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Without tube implant (13)     12.8.2 With tube implant or other drainage devices (7)     12.8.3 Non-perforating (7)     12.8.4 Using laser (0)     12.8.5 Other (1)     12.8.10 Woundhealing antifibrosis (11)     12.8.11 Complications, endophthalmitis (3)   12.9 Trabeculotomy, goniotomy (0)   12.10 Cyclodestruction (5)   12.11 Cyclodialysis (1)   12.12 Cataract extraction (0)     12.12.1 Intracapsular (0)     12.12.2 Extracapsular (0)     12.12.3 Phacoemulsification (5)   12.14 Combined cataract extraction and glaucoma surgery (0)     12.14.1 Intracapsular (0)     12.14.2 Extracapsular (1)     12.14.3 Phacoemulsification (6)   12.15 Capsulotomy (0)   12.16 Vitrectomy (0)   12.17 Anesthesia (2)   12.20 Other (1) 13 Therapeutic prognosis and outcome (0)   13.1 Prognostic factors (5)   13.2 Outcome (0)     13.2.1 IOP (1)     13.2.2 Visual field (0)       13.2.2.1 Progression (4)       13.2.2.2 Improvement (0)     13.2.3 Other (0) 14 Costing studies; pharmacoeconomics (5) 15 Miscellaneous (2)

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Abstract #19338 Published in IGR 9-3

Experimental study of mitomycin-C drug delivery system on glaucoma filtration surgery in rabbits

Zheng X; Wang G; Wei S; Gao J; Li J
Chinese Ophthalmic Research 2007; 25: 498-501

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OBJECTIVE: Topical application of intraoperative 0.2 - 0.4 mg/ml MMC can effectively inhibit subconjunctival fibroblasts and improve the successful rate of filtration surgery, but its complications produce a new threat to visual function of glaucoma patient. The objective of this study was to investigate the efficacy, feasibility and adverse effects of mitomycin C drug delivery system (MMC DDS) as a new anti-scarring agent during glaucoma surgery. METHODS: The drug delivery system was made with polymer polylactioglycolic acid (PLGA), and 0.02 mg mitomgcin C was incorporated into PLGA with a dissolving duration within 28 days. Filtering surgery model was established in both eyes of 24 white rabbits, and the right eyes received MMC DDS as experimental group, and only MMC was used in 12 left eyes and blank DDS was put in other 12 left eyes (EM DDS group). RESULTS: No evident inflammation was found in the eyes of MMC DDS group, indicating a well tolerance in surgery eyes. The filtering bleb was kept over 28 days in MMC DDS group, showing a longer period in comparison with control group. The IOP remained steady at a level of less than baseline in the MMC DDS group. The implantation of MMC DDS enhanced the MMC concentration in aqueous for 7-14 days. The collagen fibers were less 28 days after surgery in MMC DDS group under the microscope. MMC DDS reduced fibroblast activity, displaying a significant reduction in proliferating cell nuclear antigen(PCNA) expression in fibroblast. CONCLUSION: MMC DDS has strong inhibition on inflammatory cells activity and fibroblast activity in surgery sites. MMC DDS can improve filtration surgery outcome. It is of potential as a new anti-scarring agent in glaucoma filtration surgery. LA: Chinese

Dr. X. Zheng, Department of Ophthalmology, Liaocheng People's Hospital, Liaocheng 252000, China. zxl_mary@163.com

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)

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