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Abstract #19365 Published in IGR 9-3
Investigation of the association between interleukin-1β polymorphism and normal tension glaucoma
Wang CY; Shen Y-C; Su C-H; Lo F-Y; Lee S-H; Tsai H-Y; Fan S-SMolecular Vision 2007; 13: 719-723
PURPOSE: In normal tension glaucoma (NTG), factors other than elevated intraocular pressure are likely to have a role in the pathogenesis of optic neuropathy. The potential similarities in cellular apoptosis leading to neurodegeneration between Alzheimer's disease and NTG were shown in recent studies. The interleukin-1β (IL-1β (-511)) and IL-1β (+3953) polymorphisms were found to increase risk with Alzheimer's disease. The purpose of this study was to test the hypothesis that the IL-1β polymorphism is associated with NTG in the Chinese population. METHODS: This is a cohort study in a Chinese population that involved 231 people with NTG and 245 healthy controls. Genomic DNA was amplified by a polymerase chain reaction, followed by the enzymatic restriction fragment length polymorphism technique. Patients and controls were genotyped for the C/T polymorphism at position -511 and +3953 of the IL-1β gene. Genotypes for NTG and control groups were compared for statistically significant differences. RESULTS: There was no significant difference in genotype frequency or allele frequency distribution of the IL-1β gene polymorphisms (position -511 and +3953) between NTG patients and the control group (p > 0.3). CONCLUSIONS: Our study showed no evidence for an association between the IL-1β (-511) and IL-1β (+3953) polymorphisms and NTG. The IL-1β gene polymorphisms (position -511 and +3953) may not play a key role in NTG pathogenesis in Chinese population.
Dr. H.-Y. Tsai, Department of Ophthalmology, Taichung Veterans General Hospital, Taichung Harbor Road, Taichung 407, Taiwan. cywangtw@yahoo.com
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)