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Abstract #19422 Published in IGR 9-3
Meta-analysis of glaucomatous hemodynamic changes in ophthalmic artery and central retinal artery in China
Zhou GInternational Journal of Ophthalmology 2007; 7: 720-726
AIM: To evaluate the diagnostic effects of hemodynamic changes of ophthalmic artery (OA) and central retinal artery (CRA) on glaucoma. METHODS: The hemodynamic parameters measured with color Doppler ultrasonography from 40 research articles from 1994 to 2006 were cited and analyzed with meta-analysis in homogeneity test and combined test. RESULTS: The homogeneous research results of the parameters included the decrease of peak systolic velocity (0.55-0.68, 0.41-0.51 Standard Deviation, SD; respectively), end diastolic velocity (0.22-2.52, 0.69-0.79 SD; respectively) of OA and CRA in glaucomatous contralateral non-damaged eyes; OA mean velocity (0.23-0.32 SD) in post-operation patients with glaucoma; OA peak systolic velocity and end diastolic velocity (0.71-0.79, 0.68-0.77 SD; respectively) in normal tension glaucoma (NTG), CRA pulsatility index (0.04-0.11 SD) in angle-closure glaucoma, and OA mean velocity (0.06-2.25 SD) and CRA peak systolic velocity (0.34-3.81 SD) in chronic angle-dosure glaucoma (CCAG), compared to the normal. Resistive index of CRA increased in glaucomatous contralateral non-damaged eyes (0.51-0.61 SD) and in post-operation patients with glaucoma (0.04-1.51 SD), compared to the normal. OA end diastolic velocity in higher intraocular pressure group were reduced by 1.61-1.82, 1.01-1.26 and 0.47-0.79 SD, compared to the normal, slight, and mild intraocular pressure group, respectively. CONCLUSION: Ischemic changes of hemodynamics in OA and CRA are one of major pathogenetic factors of glaucomatous neuropathy damage, not only primary causative risk factor but also secondary additional effect. These changes are more severe in primary open-angle glaucoma (POAG) than in NTG and CCAG. Characteristics of the changes differ in NTG with low peak systolic and end diastolic velocities of CRA, in CCAG with low peak systolic velocity of OA and mean velocity of OA, in POAG with high resistive index. Hemodynamic parameters measured by color Doppler are important for evaluation after glaucomatous operations. LA: Chinese
Dr. G. Zhou, Department of Ophthalmology, No 12 People's Hospital of Guangzhou, Guangzhou 510620 Guangdong Province, China. kenzhou777@yahoo.com.cn
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
