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Abstract #19469 Published in IGR 9-3
Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension
Cellini M; Bernabini B; Carbonelli M; Zamparini E; Campos ECEye 2007; 21: 1071-1077
PURPOSE: To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. MATERIALS AND METHODS: We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). RESULTS: The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250 ± 14.091 vs131.750 ± 10.729 mum (P < 0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.873 ± 1.488 vs 1.938 ± 0.704 dB (P < 0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.768 ± 0.012 vs 0.745 ± 0.019 (P < 0.022), in the CRA was 0.66 ± 0.012 vs 0.645 ± 0.019 (P < 0.032), and in PCAs was 0.673 ± 0.039 vs 0.622 ± 0.012 (P < 0.037). The OCT had a sensitivity of 83%, but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. CONCLUSIONS: Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.
Dr. M. Cellini, Department of Surgery and Transplant- Ophthalmology Service, A. Valsalva, University of Bologna, Bologna, Italy. mauro.cellini@unibo.it
Classification:
9.2.1 Ocular hypertension (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
