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Abstract #19475 Published in IGR 9-3
Meta-analysis on the association of Myocilin Q368X mutation and primary open angle glaucoma
Liu T; He XGChinese Journal of Ophthalmology 2007; 43: 361-366
OBJECTIVE: To study the association between Myocilin (MYOC) Gln368STOP mutation and primary open angle glaucoma (POAG) by means of Meta-analysis. METHODS: Odds ratios (OR) of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4.2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies. RESULTS: A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed (P = 0.79). The pooled OR (with 95% CI) of MYOC Gln368STOP in POAG cases versus that in the controls was 6.01 (2.57 - 14.04, P < 0.01). CONCLUSION: MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors. LA: Chinese
Dr. T. Liu, Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China. tingliu1597@126.com
Classification:
3.4.1 Linkage studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
