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Abstract #19617 Published in IGR 9-3
Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test
Kida T; Sugiyama T; Oku H; Harino S; Ikeda TGraefe's Archive for Clinical and Experimental Ophthalmology 2007; 245: 1289-1293
PURPOSE: To determine the relationship between the changes in optic nerve head (ONH) circulation and the level of plasma endothelin-1 (ET-1) during the glucose tolerance test (GTT). METHODS: Twenty-six healthy volunteers with normal GTT and 15 patients with mild hyperglycemia and abnormal GTT were studied. The ONH circulation [square blur rate (SBR) value], blood pressure, intraocular pressure (IOP), blood glucose, blood insulin and plasma ET-1 were determined before and every hour up to 3 h after an oral intake of 75 g of glucose. RESULTS: The SBR increased in the normal glucose tolerance group at all times during the GTT, but it decreased significantly in the abnormal glucose tolerance group (P < 0.05). Before the GTT, the plasma ET-1 level was not significantly different in the two groups; however, the level increased 1 h after the oral GTT in the abnormal glucose tolerance group (P < 0.05). No significant changes were observed in mean blood pressure or IOP. CONCLUSIONS: ONH circulation increased after glucose intake in the normal glucose tolerance group and remained high even after the blood glucose level had returned to its baseline. The decrease in ONH circulation in the abnormal glucose tolerance group was attributed partly to the increased ET-1.
Dr. T. Kida, Department of Ophthalmology, Osaka Medical College, Osaka, Japan
Classification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
6.13 Provocative tests (Part of: 6 Clinical examination methods)
