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Abstract #19630 Published in IGR 9-3
Wavefront aberration and its association with intraocular pressure and central corneal thickness in myopic eyes
Qu J; Lu F; Wu J; Wang Q; Xu C; Zhou X; He JCJournal of Cataract and Refractive Surgery 2007; 33: 1447-1454
PURPOSE: To investigate the association between intraocular pressure (IOP), central corneal thickness (CCT), or both and wavefront aberrations in the anterior cornea and the whole eye in myopia. SETTING: Wenzhou Medical College, Wenzhou, Zhejiang, China. METHODS: Seventy myopic subjects were tested with a Humphrey corneal topographer for wavefront aberrations in the anterior corneal surface and with a wavefront aberration-supported cornea ablation wavefront analyzer (Complete Ophthalmic Analysis System, Carl Zeiss Meditec) for wavefront aberrations in the whole eye. The IOP and CCT were measured with a noncontact Canon tonometer and a Tomey pachymeter, respectively. Relationships between the wavefront aberrations and the IOP and CCT were analyzed. RESULTS: Four corneal Zernike aberrations were significantly correlated with the IOP, including defocus (Z4) (r = 0.36, P < .01 for right eye; r = 0.31, P < .05 for left eye), y-axis coma (Z7) (r = 0.32, P < .05 for right eye), spherical aberration (Z12) (r = 0.34, P < .02 for both eyes), and secondary astigmatism (Z13) (r = -0.35, P < .01 for right eye; r = -0.37, P < .01 for left eye). In the whole eye, 3 Zernike aberrations were significantly correlated with IOP: trefoil (Z6) (r = 0.31, P < .05 for right eye), spherical aberration (Z12) (r = 0.34, P < .02 for right eye; r = 0.30, P < .05 for left eye), and secondary astigmatism (Z13) (r = -0.45, P < .01 for right eye; r = -0.30, P < .05 for left eye). However, only a single Zernike aberration (Z11) was significantly correlated with CCT (r = -0.29, P < .05 for right eye). CONCLUSIONS: Intraocular pressure was associated with wavefront aberrations in both the cornea and the whole eye, and its association was not limited to symmetrical aberrations but included asymmetric higher-order aberrations as well. In contrast, CCT was very weakly associated with wavefront aberrations.
Classification:
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)
