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1 General aspects (0)   1.1 Epidemiology (4)   1.2 Population genetics (1)   1.3 Pathogenesis (1)   1.4 Quality of life (7)   1.5 Glaucomas as cause of blindness (1)   1.6 Prevention and screening (11) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (13)   2.3 Sclera (4)   2.4 Anterior chamber angle (3)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (8)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (1)     2.6.2 Outflow (0)       2.6.2.1 Trabecular meshwork (3)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (2)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (3)   2.9 Ciliary body (3)   2.10 Lens (1)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (24)   2.14 Optic disc (18)   2.15 Optic nerve (4)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (1)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (5)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (12)     3.4.2 Gene studies (10)   3.5 Molecular biology incl. 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(2)

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Abstract #19650 Published in IGR 9-3

The change of the level of the vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma before and after anterior retinal cryotherapy

Chen T; Zeng S-Q; Lu Y-Y; Huang L-Y; Dai H
Chinese Journal of Ophthalmology 2007; 43: 622-625

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OBJECTIVE: To compare the change of the level of the vascular endothelial growth factor (VEGF) in aqueous humor of patients with neovascular glaucoma (NVG) before and after anterior retinal cryotherapy and investigate the effects of the fluctuation of VEGF on the neovascularization of iris. METHODS: 28 patients with neovascular glaucoma were undergone iris fluorescent angiography to identify the area and amount of new vessels before and after anterior retinal cryotherapy. The neovascularization of iris was observed from 7 to 14 days by iris fluorescent angiography to confirm the regression of new vessels in iris before trabeculectomy. Samples of aqueous humor were obtained before anterior retinal crytherapy and trabeculectomy, and 30 samples of aqueous humor from patients with senile cataract were collected as normal group. The concentrations of VEGF were measured using enzyme linked immunosobent assay. RESULTS: the concentration of VEGF (2.096 &plm; 0.512) ng/ml in aqueous humor from patients with NVG were much higher than the specimen from the patients pre-trabeculectomy (0.478&plm; 0.312) ng/ml, There was a significant difference between the two groups (t = 17. 994, P < 0.01). The mean VEGF concentration of the aqueous humor from patients with senile cataract was (0. 198 &plm; 0.045 ) ng/ml which was much lower compared with the samples from patients of pre-trabeculectomy (t = 18. 453, P < 0.01). CONCLUSIONS The concentration of VEGF decline after the regression of new vessels in iris. The results suggest that VEGF play an important role in formation of iris neovascularization. Blockage the release of VEGF might reduce the occurrence of neovascular glaucoma.

Dr. H. Dai, Department of Ophthalrrwlogy, Union Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430022, China. dai-hong@x263.co

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Classification:

9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)

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