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Abstract #19715 Published in IGR 9-4
Comparative evaluation of optical coherence tomography in glaucomatous, ocular hypertensive and normal eyes
Subbiah S; Sankarnarayanan S; Thomas PA; Nelson Jesudasan CAIndian Journal of Ophthalmology 2007; 55: 283-287
BACKGROUND: To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness with visual field changes in glaucomatous, ocular hypertensive and normal eyes. MATERIALS AND METHODS: Thirty consecutive normal, 30 consecutive ocular hypertensive and 30 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, (30-2) Humphrey field analyzer white on white (W/W) perimetry and short- wavelength automated perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide OCT scans. Average and segmental RNFL thickness values were compared among all groups. A correlation was sought between global indices of perimetry and RNFL thickness. RESULTS: Of the 90 eyes enrolled (mean age of patients 52.32 ± 10.11 years), the mean RNFL thickness was significantly less in ocular hypertensive (82.87 ± 17.21 μm; P = 0.008 and glaucomatous eyes (52.95 ± 31.10 μm; P < 0.001), than in normals (94.26 ± 12.36 μm). The RNFL was significantly thinner inferiorly in glaucomatous eyes (64.41 ± 43.68 μm; P < 0.001) than in normals (120.15 ± 14.32 μm) and ocular hypertensives (107.87 ± 25.79 μm; P < 0.001). Ocular hypertensives had thinner RNFL in the nasal, inferior and temporal quadrants (P < 0.001) when compared to normals. Global indices in ocular hypertensives on SWAP showed Mean Deviation (MD) of 5.32 ± 4.49, Pattern Standard Deviation (PSD) 3.83 ± 1.59 and Corrected Pattern Standard Deviation (CPSD) 2.84 ± 1.85. The RNFL thickness could not be significantly correlated with global indices of visual fields in ocular hypertensives. CONCLUSION: Optical coherence tomography is capable of detecting changes at the level of RNFL in ocular hypertensive eyes with normal appearance of discs and W/W perimetry fields.
Dr. S. Subbiah, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, Tamil Nadu, India. umasujata@yahoo.com
Classification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)