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1 General aspects (0)   1.1 Epidemiology (11)   1.2 Population genetics (2)   1.3 Pathogenesis (4)   1.4 Quality of life (8)   1.5 Glaucomas as cause of blindness (7)   1.6 Prevention and screening (4) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (0)   2.2 Cornea (23)   2.3 Sclera (3)   2.4 Anterior chamber angle (5)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (10)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (1)       2.6.2.1 Trabecular meshwork (1)       2.6.2.2 Uveoscleral (0)     2.6.3 Compostion (3)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (2)   2.9 Ciliary body (1)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (2)   2.13 Retina and retinal nerve fibre layer (21)   2.14 Optic disc (14)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (1)   2.17 Stem cells (1)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (6)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (6)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (12)   3.5 Molecular biology incl. 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Miscellaneous (9)

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Abstract #19720 Published in IGR 9-4

Diagnostic capability of PULSAR, FDT y HRT-II in glaucoma suspects

Gonzalez de la Rosa M; Gonzalez Hernandez M; Aguilar Estevez J; Diaz Aleman T; Armas Plasencia R
Archivos de la Sociedad Española de Oftalmologia 2007; 82: 413-422

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PURPOSE: To determine the diagnostic capability of PULSAR-T30W, FDT-Threshold-N30 and HRT-II in glaucoma suspects. METHODS: Forty-seven eyes from 47 referred glaucoma suspects (GS) were examined twice with each technique. Cases with TOP-WW-MD > 6dB were excluded. Results were compared with those of 70 eyes from 70 normal controls (C). RESULTS: Mean MD value using TOP-WW in the GS group (0.96dB, SD = 1.7) was not significantly different from C (0.8dB, SD = 1.77) (p > 0.05). Disc area in GS group (2.12 mm², SD = 0.34) was significantly greater than in C (1.97 mm²>, SD = 0.45) (p < 0.01). For 95.7% specificity, PULSAR-sLV showed the highest sensitivity of 30.9% in individual examinations. The highest reproducible sensitivity in the two examinations was obtained using HRT-II maximum contour elevation (23.4%) and reference height (23.4%), and was 14.9% for various indices after correcting for the influence of disc area (cup area, cup/disc area ratio, maximum contour depression and mean RNFL thickness). Reproducible sensitivity of the perimetric indices was: PULSAR-MD = 8.5%, PULSAR-sLV = 17%, FDT-MD = 6.4%, FDT-PSD = 4.3%. The association of perimetric and HRT-II indices achieved high sensitivity but low diagnostic reproducibility. CONCLUSIONS: The most effective indices were maximum contour elevation, reference height and PULSAR-sLV, although the inclusion of the optic nerve head assessment in the selection of the GS sample may have favored the HRT-II results. LA: Spanish

Dr. M. Gonzalez-de-la-Rosa, Servicio de Oftalmologia, Hospital Universitario de Canarias, Universidad de La Laguna, Islas Canarias, Espana. mgdelarosa@jet.es

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Classification:

6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)

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