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Abstract #19759 Published in IGR 9-4
Diagnosis of open-angle glaucoma by Moorfields regression analysis and multivariate discriminate analysis
Liu C; Hu Y; Xu C; Zhu ZChinese Ophthalmic Research 2007; 25: 778-781
OBJECTIVE: Morphological analysis of the optic disk is important in the diagnosis of open-angle glaucoma. This study was to evaluate the diagnosis value of Moorfields regression analysis (MRA) and multivariate discriminate analysis (MDA, include FSM and RB) performed by the Heidelberg Retina Tomograph TJ (HRT-II) in detecting open-angle glaucomatous eyes and evaluate the difference of MRA between entire disk and sectional disk. METHODS: Seventy-five patients (79 eyes) were enrolled in the study, including 26 normal eyes, 32 suspected primary open-angle glaucoma (POAG) and 21 definite POAG. All patients underwent the examinations of HRT-II and OCTOPUS perimeter G2-TOP program. RESULTS: The statistically significant correlations between MRA, FSM, RB and visual fields defect (MD) were seen (P < 0. 01) with the Spearman correlation coefficient 0. 537, - 0. 565 and - 0. 716, respectively. Significant differences were found in MRA, FSM and RB among three groups (X2> = 53. 229, P < 0. 001; F = 90. 279, P < 0. 001; F = 57. 769, P < 0. 001; respectively). Based on the outcome of visual fields examination, the sensitivity and specificity of the MRA, FSM and RB was 92% and 88. 89% (MRA 'borderline' considered as normal), 100% and 62. 96% (MRA 'borderline' considered as abnormal), 96% and 68. 52%, 76% and 92. 59%, respectively. As increase of optic disk area, the specificities of three methods decreased. MRA and perimetry showed a better agreement in sectional disk than in the entire one for the suspect patients, and temporal-inferior sector was found to have the best agreement (78. 13%). Temporal-superior and temporal-inferior sectors exhibited the highest sensitivity and specificity in MRAs of sectional disk. CONCLUSION: MRA and MDA had considerable capability in detecting POAG and correlated moderately with MD, but it should be cautious in interpreting the results of patients with larger disk. In clinical setting, MRA seems to be more valuable in sectional disk than in the entire, especially in temporal-superior and temporal-inferior sectors. LA: Chinese
Dr. C. Liu, Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China
Classification:
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
