advertisement
Abstract #19762 Published in IGR 9-4
Effects of stress level on biomechanical properties of sclera in ped-rabbit
Jin T; Wang CChinese Ophthalmic Research 2007; 25: 641-643
OBJECTIVE: To investigate the effects of stress intensity on the biomechanical properties of the sclera of the ped-rabbit. METHODS: Twenty 21-day-old New Zealand white rabbits were randomly divided into two groups. The one eye of each rabbit was chosen as experimental eye and another one was as control. Intraocular hypertension was induced through injection of Sodium Hyaluronate into anterior chamber and balanced salt solution was used in control eye in group 1. Chronic intraocular hypotension model was created using sclerectomy, and the combination of part of iridotomy and topical administration of 0.5% Timolol eye drops was applied in another group. Ocular axis length was measured at three-month old rabbits. Eyeballs of rabbits were enucleated and the biomechanical properties of the sclera were analyzed. RESULTS: The ocular axis length was significantly increased after intraocular pressure manipulation in the intraocular hypertension group and the ocular hypotension group (P < 0.05). In the intraocular hypertension group, the axis length of experimental eyes was 15.09 ± 0.36 mm, and that in the control group was 15.01 ± 0.56 mm (P > 0.05). In the ocular hypotension group, the axis length of experimental eyes was 15.41 ± 1.19 mm and 15.40 ± 1.02 mm in the control group (P > 0.05). In the intraocular hypertension group, the variable value was (6.06 x 10-5 ± 5.57 x10-6)mL/mmH2O in experimental eyes and (6.07 x 10-5 ± 4.13 x 10-6) in control eyes (P > 0.05); while that in the ocular hypotension group was (7.04 x 10-5 ± 9.71 x10-6) mL/mmH2O and (6.59 x 10-5 ± 1.28 x 10-5) in experimental eyes and control eyes, respectively (P < 0.05). There was a significant difference between the two experimental groups (P < 0.05). CONCLUSION: The intraocular pressure ranged from 9.83 ± 0.30 mmHg to 35.10 ± 2.78 mmHg and had little impact on the ocular axis and the transformation and carrying capacity of the sclera of the younger rabbits. The regulation of sclera stress intensity through controlling intraocular pressure is a passive effect, and therefore has a completely different mechanism from the initiative influence of myopic eyes on the sclera. LA: Chinese
Dr. T. Jin, Department of Ophthalmology, Bethune International Peace Hospital, Shijiazhuang 050082, China
Classification:
2.3 Sclera (Part of: 2 Anatomical structures in glaucoma)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
