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Abstract #19849 Published in IGR 9-4
The plasma levels of Aβ(1-40) and Aβ(1-42) in Uyghur patients with normal-tension glaucoma
Wei B; Zhang H; Wang X-J; Fu L-L; Ju E-TInternational Journal of Ophthalmology 2007; 7: 1031-1033
AIM: To assess the role of β amyloid protein in pathogenesis of normal-tension glaucoma by analyzing the level difference of Aβ(1-40) and Aβ(1-42) in the plasma between Uyghur patients with normal-tension glaucoma and control groups. METHODS: Aβ(1-40) and Aβ(1-42) were assayed in 37 cases of Uyghur normal-tension glaucoma patients, 40 cases of Han nationality normal-tension glaucoma patients and 40 cases of Uyghur cataract patients by using ELISA method. RESULTS: Aβ(1-40) and Aβ(1-42) concentrations in Uyghur and Han nationality normal-tension glaucoma groups and an Uyghur cataract group were (142.4 ± 7.0)ng/L, (140.0 ± 4.2)ng/L, (120.3 ± 5.3)ng/L and (159.8 ± 5.5)ng/L, (161.1 ± 2.8) ng/L, (101.6 ± 6.5)ng/L, respectively. The mean concentrations of Aβ(1-40) and Aβ(1-42) in the Uyghur normal-tension glaucoma group were significantly higher than those of the cataract group (P < 0.05). There were no significant differences between the Uyghur normal-tension glaucoma group and the Han normal-tension glaucoma group (P > 0.05). CONCLUSION: The levels of Aβ(1-42) and Aβ (1-42) in the plasma of the Uyghur patients with normal-tension glaucoma were higher than that of the Uyghur cataract group, but were not correlated with races of Uyghur or Han nationality. LA: Chinese
Dr. B. Wei, Department of Ophthalmology, Kelamayi Central Hospital, Kelamayi 834000, China. klmyweibin@126.com
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.7 Biochemistry (Part of: 3 Laboratory methods)
