advertisement
Abstract #19944 Published in IGR 9-4
Acute increase of intraocular pressure releases ATP into the anterior chamber
Zhang X; Li A; Ge J; Reigada D; Laties AM; Mitchell CHExperimental Eye Research 2007; 85: 637-643
Throughout the body, mechanical perturbations are transduced into neurochemical signals by the release of ATP from non-neuronal cells. As an increased intraocular pressure (IOP) can initiate mechanical changes, we hypothesized that extracellular levels of ATP might be increased in the anterior chamber of human patients with primary acute angle-closure glaucoma (PAACG). ATP levels in aqueous humor samples were determined using the luciferin-luciferase assay. Samples were obtained from 18 controls scheduled for cataract extraction and from 14 subjects with angle-closure glaucoma during paracentesis. All subjects with angle-closure glaucoma had remarkably elevated levels of ATP in their aqueous humor. The mean ATP concentration was nine times higher for patients with angle-closure glaucoma than for control. The concentration of ATP was correlated with IOP levels, further supporting a causal relationship. ATP levels were not influenced by the duration of the PAACG attack, suggesting the rate of ATP release was sustained. We conclude that increased IOP leads to increased levels of extracellular ATP in the anterior chamber. This elevated ATP may contribute to the extreme pain experienced by subjects with angle-closure glaucoma, and may serve as a source of elevated adenosine in the anterior chamber.
Dr. X. Zhang, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, People's Republic of China
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
