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Abstract #19964 Published in IGR 9-4
Effects of topical travoprost and unoprostone on optic nerve head circulation in normal rabbits
Ohashi M; Mayama C; Ishii K; Araie MCurrent Eye Research 2007; 32: 743-749
PURPOSE: To evaluate the effect, and the duration of the effect, of topically administrated travoprost and unoprostone on optic nerve head (ONH) circulation in Dutch rabbits. METHODS: First, travoprost (0.004% solution) or unoprostone (0.12% solution) was unilaterally instilled once, or once daily (travoprost) or twice daily (unoprostone) for seven days in Dutch rabbits. The ONH tissue blood velocity (NB(ONH)) was measured using the laser speckle method at 30 and 60 min after a single instillation of travoprost or unoprostone, and before and at one, six, and 12 hr (travoprost or unoprostone) and 24 hr (travoprost only) after the last instillation of the aforementioned seven-day instillation regimen. Second, similar experiments were conducted with indomethacin (5 mg/kg) pretreatment. RESULTS: Both travoprost and unoprostone significantly increased NB(ONH) only in the treated eyes after a single instillation (p = 0.011 to 0.038); this effect was abolished by indomethacin pretreatment. In the seven-day instillation regimen, NB(ONH) was increased by 11%, 40%, 17%, 16%, and 12% only in the treated eyes just before and at one, six, 12, and 24 hr after the final instillation of travoprost, respectively, and increased by 10%, 25%, 13%, and 14% only in the treated eyes just before and at one, six, and 12 hr after the final instillation of the unoprostone, respectively. CONCLUSIONS: Topical travoprost or unoprostone significantly increased the ONH blood velocity with a single instillation and the effect persisted for 24 hr after a seven-day instillation. The effects of these drugs against retinal and ONH circulation are probably associated with the production of endogenous prostaglandins.
Dr. M. Ohashi, Toranomon Hospital Eye Clinic, Tokyo, Japan. Ohashi.masaaki@nifty.ne.jp
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
11.4 Prostaglandins (Part of: 11 Medical treatment)
