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Abstract #20318 Published in IGR 10-1
Peripapillary atrophy in elderly Chinese in rural and urban Beijing
Wang Y; Xu L; Zhang L; Yang H; Ma Y; Jonas JBEye 2008; 22: 261-266
PURPOSE: To determine peripapillary atrophy in elderly Chinese in an urban and rural regions of Beijing. METHODS: The Beijing Eye Study a population-based, cross-sectional cohort study, included 4439 subjects out of 5324 subjects who were asked to participate (response rate 83.4%). Mean age was 56.2±10.6 years (range, 40-101 years). Colour optic disc photographs (30 degrees ) were morphometrically examined. Peripapillary atrophy was divided into α zone and β zone. RESULTS: Optic disc photographs were available for 4027 (90.7%) subjects. Alpha zone and β zone, respectively, were present in 2867 (71.2%) subjects and 802 (19.9%) subjects, respectively, measuring 0.52±0.64 mm2 and measuring 0.46±1.82 mm2. Both zones were significantly widest and found significantly (P<0.001) most often in the temporal peripapillary region, followed by the temporal inferior region, the temporal superior region, and finally the nasal region. Size of both zones was significantly correlated with optic disc size (P<0.001), age (P<0.001), and myopic refractive error (P<0.001). Both zones increased significantly with decreasing uncorrected visual acuity (P<0.001) and decreasing best-corrected visual acuity (P<0.001). They did not vary significantly (P=0.10; and P=0.78) between male and female subjects. In multivariate analysis, the relationships between both zones and age, myopic refractive error, disc size, and uncorrected and best-corrected visual acuity remained statistically significant (P<0.001). CONCLUSIONS: Alpha zone and β zone of peripapillary atrophy, respectively, occur in about 70 and 20%, respectively, of elderly Chinese. As peripapillary atrophy changes in glaucomatous optic neuropathy, these normative data may be helpful for glaucoma detection.
Dr. Y. Wang, Department of Ophthalmology and Eye Hospital, Tongren Hospital, Beijing, China
Classification:
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
