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Abstract #20393 Published in IGR 10-1

No relation between angiotensin-converting enzyme gene polymorphism and pseudoexfoliation

Tekeli O; Turaçli ME; Altinok B; Akar N; Elhan AH
Ophthalmic Research 2008; 40: 32-34


AIMS: To determine the association between the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism and pseudoexfoliation (PEX) in Turkish patients. METHODS: This prospective study consisted of 89 patients with PEX, and 120 controls. The I/D polymorphism of the angiotensin-converting enzyme gene was measured with the use of the polymerase chain reaction method. RESULTS: The distribution of the polymorphism was not significantly different in cases with PEX and controls. The frequencies of the I and D alleles were not significantly different between the groups. CONCLUSION: According to our findings, I/D polymorphism in the angiotensin-converting enzyme gene does not play any role in the pathogenesis of PEX.

Dr. O. Tekeli, Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey. oyatekeli@tr.net


Classification:

9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)



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