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Abstract #20576 Published in IGR 10-1
Correlation of visual changes with disc morphology
Garway-Heath DFEye 2007; 21: S29-S33
The identification of glaucomatous damage and monitoring of disease progression require the measurement of both structural and functional changes. Ongoing research is focused on the relationship between these two types of changes. The purpose of this paper is to examine four aspects of the association between structural and functional changes of the optic nerve head (ONH) - the spatial relationship between changes in the ONH and visual field, the quantitative relationship between these changes, the difficulties of using summary statistics to quantify damage, and a comparison of how structure and function measurements allow us to detect progression and how these measurements agree with each other. Dissociation between structural and functional measurements may occur - it is possible that some structural change does not relate to ganglion cell loss, and some functional loss does not relate to cell loss but to dysfunction. Current data suggest that both structural and functional measurements are necessary to monitor disease progression, which is important for making clinical decisions.
Dr. D.F. Garway-Heat,. Moorfields Eye Hospital, Institute of Ophthalmology, City University, London, United Kingdom
Classification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
6.6 Visual field examination and other visual function tests (Part of: 6 Clinical examination methods)
6.9 Computerized image analysis (Part of: 6 Clinical examination methods)
