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Abstract #20580 Published in IGR 10-1
DARC: A new method for detecting progressive neuronal death
Cordeiro MFEye 2007; 21: S15-S17
Visual field evaluations are currently used as the gold standard in assessing disease progression in glaucoma, but this method considers damage that has irreversibly occurred. If retinal ganglion cell (RGC) apoptosis can be detected, it may be possible to prevent loss of vision, and also to act at a much earlier stage to avoid the secondary degeneration of neurons and progression of the disease. Detection of apoptosing retinal cells (DARC) is a method that uses advanced optical techniques to image and track the process of RGCs in vivoover time. It has the potential to help elucidate the cellular mechanisms involved in the development of RGC degeneration and vision loss in glaucoma.
Dr. M.F. Cordeiro, UCL, Institute of Ophthalmology, Western Eye Hospital, London, United Kingdom
Classification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
6.9.5 Other (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
