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Abstract #20604 Published in IGR 10-1
Zebrafish mutants as models for congenital ocular disorders in humans
Gross JM; Perkins BDMolecular Reproduction and Development 2008; 75: 547-555
Over the last 15 years, the zebrafish has provided an ideal animal model system to study human ocular disorders. Forward genetic screens have identified a number of mutants that serve as excellent models for coloboma, cataracts, and photoreceptor and RPE pathologies. Ongoing screens in several laboratories, utilizing transgenic strains and more advanced screening techniques, as well as the positional cloning of affected loci in many, as yet, unidentified mutants promises to continue this trend for many years to come.
Dr. J.M. Gross, Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. jmgross@mail.utexas.edu
Classification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
