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Abstract #20702 Published in IGR 10-1
Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery
Ozkurt Y; Oral Y; Karacan O; Comez A; Dogan OKEye Contact Lens 2008; 34: 21-23
PURPOSE. To compare the effects of dorzolamide-timolol combination and brimonidine on intraocular pressure (IOP) after phacoemulsification surgery. METHODS. This prospective, randomized study included 69 eyes of 43 patients undergoing phacoemulsification and foldable intraocular lens implantation. Twenty-one patients were women and 22 were men. The mean patient age was 69.7 ± 12.4 years. Patients were randomly assigned to one of three treatment groups preoperatively. Group A (n = 23) received one drop of dorzolamide-timolol fixed combination and group B (n = 23) received one drop of brimonidine tartrate 0.2% immediately after surgery. In group C (n = 23), patients received no treatment and served as a control group. IOP was measured by Goldmann applanation tonometry 6 hours and 24 hours after surgery. RESULTS. Six hours after surgery, the mean IOP was significantly lower in group A (16.3 ± 2.9 mmHg) than in groups B (20.6 ± 2.9 mmHg) and C (24.6 ± 5.4 mmHg). However, 24 hours after surgery, the mean IOP was higher in group C (19.8 ± 4.7 mmHg) than in the other two groups (14.1 &plusm; 2.8 mmHg in group A and 17.5 ± 2.7 mmHg in group B). CONCLUSIONS. Prophylactic treatment with dorzolamide-timolol fixed combination was more effective than brimonidine in reducing IOP 6 hours and 24 hours after phacoemulsification surgery.
Dr. Y. Ozkurt, PTT Hospital, Korkut. Sok. Dumankaya Evleri A1 B Blok Sen Apt 917, Kozyatagi-Istanbul, Turkey
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.13.2 Betablocker and carbon anhydrase inhibitor (Part of: 11 Medical treatment > 11.13 Combination therapy)