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Abstract #20727 Published in IGR 10-1
Retrobulbar hemodynamic changes in acute angle-closure glaucoma patients detected by color Doppler flow imaging
Zhao F; Wang FJournal of Clinical Rehabilitative Tissue Engineering Research 2007; 11: 9714-9717
AIM: To observe retrobulbar hemodynamic changes in acute angle-closure glaucoma (AACG) patients using color Doppler flow imaging, and analyze the application value of color Doppler flow imaging to assess ophthalmic diseases. METHODS: 1 From January to December in 2003, 28 AACG patients (31 eyes) were recruited from the Nanjing First Hospital of Nanjing Medical University, with the average intraocular pressure of (6.88&plusm;0.37) kPa; 20 healthy volunteers who matched well in age and gender were taken as normal control group, and their average intraocular pressure was (2.13±0.67) kPa. Informed consents were obtained from all the subjects, and the experiment was approved by the hospital ethics committee. 2 Philips ATL 5000 color Doppler flow imaging analyzer was used to measure retrobulbar blood flow of normal controls and 28 AACG patients before and after operation, respectively. The measurements included peak systolic velocity (PSV), end diastolic velocity (EDV) and resistent index (RI) in the central artery of retina, short posterior ciliary artery and ophthalmic artery. RESULTS: All of 48 subjects were involved in the result analysis. 1 Compared with normal control group, PSV and EDV were decreased while RI was elevated in central artery of retina and short posterior ciliary artery of AACG group (P < 0.01). 2 The hemodynamic of AACG group after operation had significant improvement after trabeculectomy, PSV and EDV were elevated while RI was decreased. 3 Intraocular pressure of AACG patients after trabeculectomy restored to the normality, RI and EDV of short posterior ciliary artery in AACG group were still inferior to normal control group (P < 0.05). CONCLUSION: 1 AACG patients have more insufficiency of blood flow than normal person; Trabeculectomy can effectively improve ophthalmic blood flow. 2 Color Doppler flow imaging is a potential approach to evaluate and monitor glaucoma. LA: Chinese
Dr. F. Zhao, Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006 Jiangsu Province, China. 0120065@163.com
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)