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Abstract #20800 Published in IGR 10-1
Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion
Noergaard MH; Bach-Holm D; Scherfig E; Bang K; Jensen PK; Kiilgaard JF; Stefánsson E; la Cour MInvestigative Ophthalmology and Visual Science 2008; 49: 1136-1141
PURPOSE: To study the effect of dorzolamide on the preretinal oxygen tension (RPO2) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS: Experimental BRVO was induced by diathermy close to the optic disc. RPO2 was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO2 was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO2 was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide. RESULTS: The average baseline RPO2 was 2.64 ± 0.09 kPa (mean ± SD). In the BRVO-affected areas, RPO(2) decreased significantly (by 0.67 ± 0.29 and 0.94 ± 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO(2) increased significantly (by 0.51 ± 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO2 was 0.67 ± 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO2 significantly (by 0.36 ± 0.21 kPa at 3 to 4 hours and by 0.67 ± 0.40 kPa) 1 week after BRVO induction. CONCLUSIONS: Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.
Dr. M.H. Noergaard, Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)