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Abstract #20923 Published in IGR 10-2
Effect of topical mitomycin C on corneal endothelium
Panda A; Pe'er J; Aggarwal A; Das H; Kumar A; Mohan SAmerican Journal of Ophthalmology 2008; 145: 635-638
PURPOSE: To evaluate patients with ocular surface squamous neoplasia (OSSN) on treatment with topical mitomycin C (MMC) with regard to changes in corneal thickness and endothelial count. DESIGN: Prospective, nonrandomized, interventional series. METHODS: In this prospective evaluation, 25 patients with OSSN with different clock hours of involvement (range, one to eight), age varying from 19 to 76 years, were treated with topical MMC 0.04% in a cyclic manner. Preoperative corneal thickness measurement and endothelial cell density were obtained, and the tests were repeated after one, three, and six months of complete resolution. The fellow eyes of the same patients served as controls. RESULTS: Mean ± standard deviation (SD) pachymetry and endothelial cell counts before and after instillation were 504.48 ± 5.45 μm and 2325.76 ± 192.52 cells/mm2 and 503.52 ± 5.75 μm and 2297.60 ± 192.08 cells/mm2, respectively, suggesting no significant difference in the above two parameters. Similarly, in the fellow control eyes, mean ± SD pachymetry and endothelial cell counts before and after instillation were 502.80 ± 4.34 μm and 2326.72 ± 191.93 cells/mm2 and 504.64 ± 5.19 μm and 2313.60 ± 192.03 cells/mm2, respectively. CONCLUSIONS: Topical 0.04% MMC drops do not significantly affect the corneal endothelium. However, its judicious use and long-term follow-up are mandatory.
Dr. A. Panda, Cornea, Ocular Surface Disease, and Refractive Surgery Services, Dr R P Centre, All India Institute of Medical Sciences, New Delhi, India
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
