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Abstract #20943 Published in IGR 10-2
The effect of sildenafil on ocular blood flow
Harris A; Kagemann L; Ehrlich R; Ehrlich Y; López CR; Purvin VABritish Journal of Ophthalmology 2008; 92: 469-473
Sildenafil is a potent phosphodiesterase (PDE) 5 inhibitor that is used for patients with erectile dysfunction. Sildenafil induces vasodilation in selected smooth muscle via increased levels of guanosine 3', 5' cyclic monophosphate and increase in nitric oxide. The vasodilatory effects of the PDE 5 inhibitors led us to review its effect on the ocular vasculature. Sildenafil appears to increase blood flow velocity significantly in the retrobulbar and choroidal circulation. Most studies suggest an increase in choroidal blood flow, with a lesser effect on the retinal vasculature.
Dr. A. Harris, Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA. alharris@indiana.edu
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
