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Abstract #21144 Published in IGR 10-2
Postoperative follow-up of non-penetrating trabecular surgery with UBM
Zhu Y; Wang J; Li XChinese Ophthalmic Research 2008; 26: 141-144
OBJECTIVE: Non-penetrating trabecular surgery (NPTS) is a new filtrating surgery without opening in ternal trabecular structures. The purpose of this paper was to evaluate the effect of NPTS with mitomycin C (MMC) and amniotic membrane (AM) implantation in patients with primary open-angle glaucoma (POAG) and assess the validity of ultrasound biomicroscopy (UBM) in postoperative follow-up of NPTS. METHODS: NPTS with MMC and AM implantation was performed on 30 eyes of 21 patients with POAG aged 28-51 years. Intraocular pressure (IOP), visual acuity and the filtrating bleb appearance were recorded. UBM of the sclerectomy site was performed 1, 3, 6, 9, 12 and 18 months after surgery. Some parameters including conjunctival filtrating bleb appearance, condition of suprascleral aqueous lake, the thickness of residual trabeculocorneal membrane and condition of amniotic membrane were assessed. RESULTS: IOP of postoperation (15.7 ± 3.7) mmHg was significantly lower than that of preoperation (37.3 ± 5.9) mmHg in all patients (t = 4.82, P < 0.01 ). At the end of follow-up, IOP was controlled effectively in all patients. There was no significant difference in visual acuity between preoperation and 1 month postoperation (χ2 = 8.814, P = 0.266). The functional filtrating bleb was existed in 14 eyes (46.67%) during the follow-up. The margin of anterior aqueous lakes was rough gradually. In 1-18 months after operation, the volume of anterior aqueous lakes was changed significantly and contracted gradually in comparison with preoperation (F = 38.885, P = 0.000 ). Amniotic membrane implant was not degradated until 9 months in postoperation and the transparent liquid space was not found under the scleral flap. The residual trabeculocorneal membrane was roughened eccentricly. CONCLUSION: NPTS with MMC and AM implant can effectively reduce IOP in patients with POAG in long-term. UBM is a new noninvasive method for postoperative observation of NPTS. AM has not the anti-fibrotic properties and facilitate aqueous outflow through the subconjunctival space. LA: Chinese
Dr. Y. Zhu, Eye Center, Affiliated Hospital, Weifang Medical College, Weifang 261031, China. Yg_zhu.md@tom.com
Classification:
12.8.3 Non-perforating (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)
