advertisement
Abstract #21254 Published in IGR 10-2
Neuroprotection of progesterone on retinal ganglion cells in chronic ocular hypertension model rats
Xu S-L; Yin Y; Gu G-Z; Gao Z-ZJournal of Jilin University Medicine Edition 2008; 34: 226-229
OBJECTIVE: To observe the protective effect of progesterone (PROG) on rat retinal ganglion cells (RGCs) in chronic ocular hypertention models. METHODS: The chronic ocular hypertention rat model was made by cauterizating three episcleral veins. Rats were divided into control group, high level PROG group, middle level PROG group, low level PROG group according to different concentrations of PROG injected intraperitoneally. The left eye was model eye and the right eye was control eye. Three months later, the animals were executed and the eyeballs were enucleated. The RGCs were detected by HE staining and Thy-1. 1 immunohistological staining. The apoptosis of RGCs was detected by TdT-dUDP terminal nick end-labeling (TUNEL) technique. RESULTS: The number of RGCs of model eyes in high level PROG injection group was more than those in control group, low level and middle level groups (P < 0.05). And the number of TUNEL positive cells in high level PROG group was less than those in control group, low level and middle level groups (P < 0.05). CONCLUSION: PROG has neuroprotection on RGCs in rat chronic glaucoma model and the neuroprotection may be connected with concentrations of PROG. LA: Chinese
Dr. S.-L. Xu, Department of Ophthalmology, Jinlin University, Changchun 130041, China. xushaolin2005@yahoo.com.cn
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
