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Abstract #21256 Published in IGR 10-2
Evoluation on neuroprotection of memantine in acute elevated IOP
Li Y-L; Li J-MJournal of Dalian Medical University 2008; 30: 87-89
Glaucoma is one of the world's major causes of blind eye diseases. The main risk factors of glaucoma is high intraocular pressure (IOP). The rush elevated IOP produces neuronic excitotoxicity. It can cause retinal ganglion cells (RGC) death and lead to the damage of nervus opticus finaly. The study of current found that N-methyl-D-aspartate (NMDA) memantine, an uncompetive N-methyl-D-aspartate (NMDA) receptor antagonist, can dramatically reduce the degree of nervus opticus damage caused by acute elevated IOP. LA: Chinese
Dr. Y.-L. Li, Department of Ophthalmology, Dalian Medical University, Dalian 116027, China
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
