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Abstract #21272 Published in IGR 10-2
Expression of NF-κB affected by AG on retina of rats with chronic IOP elevation
Nie Q-Z; Wang Y-S; Sha Q; Gao D-WInternational Journal of Ophthalmology 2008; 8: 280-283
AIM: To study the changes of rat retinal NF-κB, as well as the effect on its changes while using amino-guanidine (AG) during the course of chronic intraocular pressure (IOP) elevation; to explore the protection of AG to retina with chronic IOP elevation. METHODS: Immunohistochemistry and western blot were used respectively to observe the changes of expression of NF-κB in retina and retinal morphological differences between the rats treated and not treated by AG at different time points during the course of chronic IOP elevation. RESULTS: With the proceeding of IOP elevation, the gradual thinning of the retina and the decrease in the number of ganglion cells were perceived, while the expression of NF-κB was increased. Between two groups of rats with chronic IOP elevation, the group using AG had minor morphological changes compared with the group which were not treated by AG, while NF-κB expression was significantly increased (P < 0.05). CONCLUSION: The nuclear transcription factor (NF-κ B) is a protective factor against retinal injury in the process of chronic IOP elevation, and AG can upregulate its expression to protect the retina. LA: Chinese
Dr. D.-W. Gao. Department of Ophthalmology, China Medical University, Shenyang 110004 Liaoning Province, China. Gaodw@cmu2h.com
Classification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)