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Abstract #21273 Published in IGR 10-2
Changes of the multifocal electroretinogram in early primary angle-closure glaucoma patients
Yu J-N; Yang X-G; Guo B; Liu Z; Ma Q-L; Li H-M; Liu J-R; Pan A-ZInternational Journal of Ophthalmology 2008; 8: 745-748
AIM: To observe the changes of the multifocal electroretinogram (mfERG) in patients with early primary angle-closure glaucoma (PACG) and to evaluate further the effects of PACG on the retinal function. METHODS: The multifocal electrophysiological examination system (RETIscan 3. 15 version, Roland, Germany) was applied to mfERG examinations in 20 patients diagnosed as early PACG and 20 healthy volunteers as control. These waves of four quadrants of SN, IN, IT, ST and 6 rings and the sum responses from the mfERG examinations were observed, and the average density of the sum response and the latent period of P1 and N1 waves were analyzed in SPSS 13.0. RESULTS: The average density of the sum response of P1 and N1 waves in the PACG group were 23.33 ± 8.67 and 9.12 ± 2.74 nV/°2 respectively, which were lower than those in normal control group (P < 0.05). The average density of P1 in SN, IN, IT and ST quadrants in the PACG group were 24.89 ± 10.18, 24.64 ± 9.27, 23.79 ± 7.97 and 21.45 ± 7.88 nV/deg2 respectively, which were lower than those in normal control group (P < 0.05). There were no statistic differences in the N1 waves between two groups. The average density of P1 in Ring 1 to Ring 6 and N1 in Ring 1, 2, 3 and 5 in the PACG group were 60.23 ± 27.76, 46.90 ± 19.85, 37.86 ± 15.14, 30.25 ± 11.52, 22.45 ± 9.59, 18.58 ± 6.56, 18.92 ± 9.72, 13.78 ± 6.26, 11.29 ± ; 4.63 and 6.90 ± 2.51 nV/deg2 respectively, which were lower than those in the normal control group (P < 0.05). CONCLUSION: There may be some characteristic changes of mfERG under the effect of intraocular pressure in PACG, such as decreased average density of the sum response, decreased average density of P1 in 6 rings and N1 in internal 3 rings. The decreased wave amplitude of P1 and N1 in external 2 rings may suggest the retina of 15 degree from the macula lutea was destroyed in the early period of PACG. LA: Chinese
Dr. X.-G. Yang, Shaanxi Eye Medical Center, Fourth Hospital of Xi'an City, Xi'an 710004 Shaanxi Province, China. yangxinguang62@hotmail.com
Classification:
9.3.1 Acute primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
