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Abstract #21285 Published in IGR 10-2
Effect of antiglaucoma agents on postoperative intraocular pressure after phacoemulsification with viscoelastics
Xie X-H; Mao A-ZInternational Journal of Ophthalmology 2008; 8: 516-518
AIM: To investigate the effectiveness of antiglaucoma ragents in preventing intraocular pressure (IOP) elevation during the early period after phacoemulsification with the help of viscoelastics. METHODS: One hundred and fifty patients (150 eyes) with uncomplicated cataract were scheduled for phacoemulsification using sodium hyaluronate as adjunct. Patients were randomly assigned to five groups: postoperative application of topical Azopt 10g/L, Alphagan 2g/L, oral acetazolamicle 250mg, timolol 5g/L, and no ocular hypotensive agent (control group). The IOP was measured preoperatively as well as 6 hours, 12 hours, 24 hours, and 1 week after surgery. RESULTS: The mean preoperative IOP values were not significantly different between groups. At 6, 12 and 24 hours postoperatively, the mean IOP was significantly lower in all groups receiving an ocular hypotensive agent than that in the control group (P < 0.01). At 6 hours after surgery, the mean IOP significantly increased in all groups but was not as prominent as the control group. At 12 hours after surgery the mean IOP was at the peak in all groups. The percentage of eyes with IOP higher than 21 mmHg at 12 hours after phacoemulsification were not significantly different between antiglaucoma agent groups, but IOP is obviously higher in the control group. At 24 hours after surgery, the mean IOP decreased significantly in all ocular hypotensive agent groups, but remained significantly high in the control group. One week after surgery, there were no significant differences between groups. CONCLUSION: All of the hypotensive agents have similar effects in reducing IOP increase after phacoemulsification performed with sodium hyaluronate as adjunct. LA: Chinese
Dr. X.-H. Xie, Department of Ophthalmology, The Second People's Hospital, Yueyang 414000 Hunan Province, China. xiexianhua73@163.com
Classification:
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5 Carbonic anhydrase inhibitors (Part of: 11 Medical treatment)
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
