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Abstract #21286 Published in IGR 10-2
Effects of enantiomers (R, R) - XY and (S, S) - XY on ocular blood flow in rabbits
Peng J; Zou Y-H; Jiang W; Ji X-B; Chen X-Y; Zhang Y-H; Peng S-X; Chiou GCYInternational Journal of Ophthalmology 2008; 8: 437-441
AIM: To evaluate the effects of two series of enantiomers [(R, R)-XY-1 through (R, R)-XY-12 and (S, S)-XY-1 through (S, S)-XY-12] on ocular blood flow in rabbits. METHODS: Colored microsphere technique was used for in-vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive (40 mmHg) rabbit eyes. RESULTS: Of the twelve compounds of (R, R)-XY series examined, four increased choroidal blood flow at 10g/L, 50 μL instilled into eyes. All compounds of (S, S)-XY series were not effective on ocular blood flow. CONCLUSION: Some compounds of (R, R)-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, (R, R)-XY-1 and (R, R)-XY-9 seem to be the most potent ones.
Dr. G.C.Y. Chiou, Institute of Ocular Pharmacology, Department of Neuroscience and Experimental Therapeutics, Texas A and M University System Health Science Center, College Station, TX 77843, USA. chiou@medicine.tamhsc.edu
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
