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Abstract #21361 Published in IGR 10-2
Penetration of topically applied levofloxacin into eyes with thin-wall filtering bleb after trabeculectomy
Qiao LY; Wang NL; Liang YB; Zhu SQ; Wan XH; Lee PYEye 2008; 22: 666-670
PURPOSE: To investigate the comparative penetration of 0.3% levofloxacin eye drops into the aqueous humour between cataract patients with or without (control) thin-wall filtering blebs. METHODS: One drop of 0.3% levofloxacin was administered to the eyes at 30-min intervals for 3.5 h before phacoemulcification for both groups. Aqueous humour samples (0.1-0.2 ml) were aspirated during surgery. The concentration of levofloxacin in the aqueous humour was determined by high-performance liquid chromatography. The Student's t-test, Pearson correlation, and Χ2 test were used to compare the data of the two groups. A P < 0.05 was required for results to be considered statistically significant. RESULTS: The levofloxacin concentration in the aqueous humour was significantly increased (P < 0.0001) in the bleb (mean + SD: 3.7 ± 2.3 mug/ml) vscontrol group (0.4 ± 0.2 mug/ml). Intraocular pressure and the bleb area were not correlated with levofloxacin concentration. CONCLUSION: The presence of thin-wall filtering blebs increases intraocular penetration of topically administered levofloxacin.
Dr. L.Y. Qiao, Guangzhou Zhongshan Ophthalmic Center, Sun Yatsen University, Guangzhou, China
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)
12.8.1 Without tube implant (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
