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Abstract #21469 Published in IGR 10-3
Brimonidine purite 0.1% versus brinzolamide 1% as adjunctive therapy to latanoprost in patients with glaucoma or ocular hypertension
Day DG; Hollander DACurrent Medical Research and Opinion 2008; 24: 1435-1442
OBJECTIVE: To evaluate the efficacy and tolerability of brimonidine purite 0.1% in comparison to brinzolamide 1% when used as adjunctive therapy to latanoprost 0.005% in patients with glaucoma or ocular hypertension. METHODS: Randomized, single-center, investigator-masked, parallel-group clinical study. Patients with IOP ≥ 18 mmHg while on once-daily latanoprost were randomized to adjunctive treatment with brimonidine purite TID (n = 20) or brinzolamide TID (n = 20) for 3 months. Intraocular pressure (IOP) was measured at 8 a.m., 10 a.m., and 4 p.m. at latanoprost-treated baseline and after 1 and 3 months of latanoprost and adjunctive therapy. A patient questionnaire was administered to evaluate the tolerability of eye drop instillation. RESULTS: Baseline mean diurnal IOP (± standard deviation, mmHg) on latanoprost was comparable between groups (brimonidine purite: 19.6 ± 2.94; brinzolamide: 19.8 ± 3.25; p = 0.846). Mean diurnal IOP at Month 3 was 16.3 ± 2.63 mmHg with brimonidine purite and 17.8 ± 2.19 mmHg with brinzolamide (p = 0.028). Adjunctive use of brimonidine purite provided greater IOP lowering than brinzolamide at 10 a.m. (p < 0.001) and 4 p.m. (p = 0.050) and equivalent IOP lowering to brinzolamide at 8 a.m. (p = 0.716). Blurred vision at Month 1 and bitter taste at Months 1 and 3 were more common upon instillation of brinzolamide eye drops. CONCLUSION: Brimonidine purite 0.1% provided significantly lower IOP compared with brinzolamide 1% when used as adjunctive therapy to latanoprost. Both adjunctive therapies were well tolerated. Limitations of this study include the use of a single site and the sample size. Additional studies are needed to further evaluate these drugs as adjunctive therapy to prostaglandin analogs.
Dr. D.G. Day, 5505 Peachtree-Dunwoody Road, Atlanta, GA 30342, USA. dougday@bellsouth.net
Classification:
11.13.5 Other (Part of: 11 Medical treatment > 11.13 Combination therapy)
