advertisement
Abstract #21488 Published in IGR 10-3
Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open-angle glaucoma
Rismanchian A; Eslami F; Moeini H; Attarzade H; Naderibeni ASaudi Medical Journal 2008; 29: 384-387
OBJECTIVE: Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open-angle glaucoma METHODS: The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups. RESULTS: A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mmHg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mmHg for the dorzolamide/timolol group. The 2 therapies were similarly effective. CONCLUSION: The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.
Dr. A. Rismanchian, Department of Ophthalmology, Isfahan University of Medical Science, Feiz Hospital, Isfahan, Iran
Classification:
11.13.2 Betablocker and carbon anhydrase inhibitor (Part of: 11 Medical treatment > 11.13 Combination therapy)
11.4 Prostaglandins (Part of: 11 Medical treatment)
