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Abstract #21640 Published in IGR 10-3
Observation study on the relationship between the asymmetry of intraocular tension and glaucoma without previous diagnosis and treatment in Shaanxi rural people aged above 50
Zhang X-L; Ren B-C; He Y; Chen L; Sun N-X; Yang J-GInternational Journal of Ophthalmology 2008; 8: 1194-1197
AIM: To investigate the asymmetrical distribution of IOP in a rural population in the Shaanxi province and review the relationship between it and glaucoma without previous diagnosis. METHODS: By using a stratified cluster random sampling technique, a total of 2 125 persons aged above 50 years were taken from Yang County, Jingbian County and Fuping County in Shaanxi province during the period of July to December in 2003. All participants had an interview with a standard questionnaire, including questions related to glaucoma of previous diagnosis and treatment, family history, the onset history and history of operation. At the same time, a detailed and relative eye examination was performed, including visual acuity, intraocular pressure, external eye examination, anterior segment of eye, peripheral anterior chamber depth, fundus examination and so on. A further examination was performed to these persons with suspicious glaucoma, including repeated tonometric examination, gonioscopy, provocative test, automated visual field testing, etc. When the difference of bilateral IOP ≥ 3 mmHg was defined as asymmetrical intraocular tension. Cases with patients after cataract operation, glaucoma with previous diagnosis and treatment and person with unconfirmed IOP were excluded. RESULTS: Total 1 775 participants were more than 50 years old, a response rate of 83.53%, in which 83 participants were excluded because they accepted cataract operation, received previous glaucomatous diagnosis and treatment and had unconfirmed IOP in the past. Eventually, 1 692 participants corresponded to the analytical standard. In this population, 23 participants were not found the previous diagnosis of glaucoma, the prevalence was 1.36% [95% confidence interval (CI), 0.88-2.071, 124 participants were found to have the asymmetry of intraocular tension, the prevalence was 7. 3% (95% CI, 6.2-8.7). With Mantel-Haenszel analyses, the prevalence of the asymmetry of intraocular tension was increasing obviously with aging (P = 0.012). The prevalence of subjects with the asymmetry of intraocular tension of whom the highest IOP > 21 mmHg was 35.7%, which was higher than that for subjects whose the highest IOP ≤ 21 mmHg (7.1%). With multiple logistic analyses, the asymmetry of intraocular tension has conspicuous association with glaucoma without definite diagnosis (OR:3.68, 95% CI, 1.37-9.86), and this relationship was also existed in subjects whose the highest IOP ≤ 21 mmHg (OR:4.74, 95% CI, 1.16- 19.35). CONCLUSION: To normal tension glaucoma without definite diagnosis, the asymmetry of intraocular tension may become an useful diagnostic indication. LA: Chinese
Dr. X.-L. Zhang, Department of Ophthalmology, The First Hospital of Xi'an Jiaotong, University School of Medicine, Xi'an 710061 Shaanxi Province, China. zhangxle@mail.xjtu.edu.cn
Classification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
