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Abstract #21641 Published in IGR 10-3
Apoptosis of retinal cells and its modulating gene bcl-2
Chen W; Peng X-JInternational Journal of Ophthalmology 2008; 8: 1236-1238
In some ocular diseases such as retinal light damage, retinal degenerations, glaucoma, etc, apoptosis plays important role in the death of retinal photorecept or cell, ganglial cells and some other retinal cells, which is the major fact of the visual function loss. Among the proteins coded by the genes of bcl-2 family, bcl-2, bcl-xl, mcl-1 bag-1 and a1 act as death repressors, whereas bax, bak, bcl-Xs, bik and bad promote cell death. These different functions were shown to be mediated by homodimerzation/heterodimerization of the various family members. Therefore, a critical balance between molecules above may determine the fate of cells in response to apoptosis-inducing conditions. We focused on the changes of Bcl-2 expression and its related mechanism in some ocular diseases which companions apoptosis of retinal cells. LA: Chinese
Dr. X.-J. Peng, Department of Ophthalmology, Navy General Hospital of Chinese PLA, Beijing 100037, China. PXJ1@rip.sina.com
Classification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)