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Abstract #21645 Published in IGR 10-3
Expression of type I, III and IV collagen fibrils in iris of primary angle-closure glaucoma
Wei H-Y; He Z-J; Wang H; Yu CInternational Journal of Ophthalmology 2008; 8: 893-895
AIM: To study the changes of collagenous fibrils in iris of primary angle-closure glaucoma and to provide evidence for researches on iris biomechanics and pathogenesis of primary angle-closure glaucoma. METHODS: Normal iris root in 11 cases without oculopathy and primary angle-closure glaucoma iris root in 29 cases were fixed into 40g/ L formalin for 48 hours, and then were embed ded by paraffin and observed by immunohistochemistry. RESULTS: Type I, III and IV collagen distributed in iris stroma and blood vessel wall. Type I collagen was expressed lower in primary angle-closure glaucoma. There was no difference in the distribution of type III or IV collagen between the two groups. CONCLUSION: The lower expression of type I collagen indicates that the decrease of iris anti-tension ability may be involved in the pathogenesis of primary angle-closure glaucoma. LA: Chinese
Dr. Z.-J. He, Department of Opthalmology, General Hospital of Tianjin Medical University, Tianjin 300052, China. yruhzj@163.com
Classification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
3.3 Immunohistochemistry (Part of: 3 Laboratory methods)