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Abstract #21673 Published in IGR 10-3
Central corneal thickness and endothelial cell density in congenital glaucoma
Guigou S; Coste R; Denis DJournal Français d'Ophtalmologie 2008; 31: 509-514
PURPOSE: The aim of this study was to compare endothelial cell density and central corneal thickness between eyes with congenital glaucoma and normal eyes. MATERIAL AND METHODS: We conducted a prospective study of pediatric patients between 3 and 18 years of age. Group A comprised 401 normal eyes and group B 69 glaucoma eyes, categorized into three subgroups: 3-4, 5-9, and 10 or more years of age. Measurements were taken using the Topcon SP 2000 specular microscope. RESULTS: The mean pachymetry in group B (519 ± 34 μm) was significantly thinner than in group A (529 ± 32 μm) (p < 0.05). There was a significant positive correlation with age in the two groups (p < 0.05 ANOVA) until the 5- to 9-year-old subgroup. The mean endothelial cell density in group B (2,922 ± 553 cells/mm2) was lower than in group A (3,470 ± 357 cells/mm2) (p < 0.01). There was a significant negative correlation with age in group A (p < 0.01 ANOVA). DISCUSSION: Corneal distension attributable to intraocular hypertony may explain the thinner pachymetry. In congenital glaucoma, a thinner cornea may tend to lower tonometrically recorded intraocular pressure. Glaucoma seems to be the main factor of the endothelial cell loss. CONCLUSION: Central corneal thickness and endothelial cell density should be taken into account when managing congenital glaucoma to avoid undertreatment and to measure endothelial damage. LA: French
Dr. S. Guigou, Service d'Ophtalmologie, CHU Nord, Marseille, France
Classification:
9.1.1 Congenital glaucoma, Buphthalmos (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
