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Abstract #21675 Published in IGR 10-3
Timolol concentrations in breast milk of a woman treated for glaucoma: Calculation of neonatal exposure
Madadi P; Koren G; Freeman DJ; Oertel R; Campbell RJ; Trope GEJournal of Glaucoma 2008; 17: 329-331
A 32-year-old lactating woman with open-angle glaucoma used timolol maleate 0.5% eye drops twice daily to her right eye for 6 months. Four milk samples were collected over a span of 6 days. Timolol maleate milk levels were examined by liquid chromatography tandem mass spectrometry and found to be at a mean of 0.12 ng/mL (range, 0 to 0.37 ng/mL). At this level, the theoretical maximum relative infant dose expressed as a percentage of the weight-adjusted maternal dose was 0.012%. As most glaucoma patients administer drops to both eyes, the dosage was duplicated to reflect the more pertinent calculated theoretical relative infant dose of 0.024%. This dose of timolol is unlikely to cause systemic side effects to the healthy breastfed infant.
Dr. P. Madadi, Department of Physiology and Pharmacology, University of Western Ontario, Ontario, Canada. pmadadi@uwo.ca
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)