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Abstract #21682 Published in IGR 10-3
Long-term relationship between intraocular pressure and visual field loss in primary open-angle glaucoma
Inatani M; Iwao K; Inoue T; Awai M; Muto T; Koga T; Ogata-Iwao M; Hara R; Futa R; Tanihara HJournal of Glaucoma 2008; 17: 275-279
PURPOSE: To investigate the dependence upon intraocular pressure (IOP) of the progression of visual field defects in eyes with primary open-angle glaucoma (POAG), in which the mean IOP was maintained at ≤ 21 mmHg. METHODS: This study involved 100 eyes with POAG, which were followed up for ≥ 5 years. The mean IOP levels were maintained at ≤ 21 mmHg during the follow-up period. The relationship between the IOP and the progression of visual field defects, which was scored using the Advanced Glaucoma Intervention Study criteria, was investigated retrospectively. RESULTS: Compared with the baseline scores, the visual field defect scores had significantly worsened by the end of the follow-up period (P < 0.0001, Wilcoxon paired signed rank test). The change in the visual field defect score (2.5 ± 0.5) in eyes with average IOP levels of ≥ 16 mmHg (n = 36) was significantly greater (P = 0.031, Mann-Whitney U test) than the change (1.3 ± 0.3) in eyes with average IOP levels of < 16 mmHg (n = 64). Moreover, IOP of ≥ 18 mmHg made a major contribution to the aggravation of visual field defects in eyes with POAG. CONCLUSIONS: Eyes with POAG and with mean IOP levels maintained at ≤ 21 mmHg underwent IOP-dependent progression of their visual field defects. Our results suggest that further IOP lowering would be beneficial in such cases.
Dr. M. Inatani, Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Japan. inatani@fc.kuh.kumamoto-u.ac.jp
Classification:
6.20 Progression (Part of: 6 Clinical examination methods)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
