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Abstract #21684 Published in IGR 10-3
Oxidative stress in primary open-angle glaucoma
Zanon-Moreno V; Marco-Ventura P; Lleo-Perez A; Pons-Vazquez S; Garcia-Medina JJ; Vinuesa-Silva I; Moreno-Nadal MA; Pinazo-Duran MDJournal of Glaucoma 2008; 17: 263-268
PURPOSE: To analyze oxidative stress in primary open-angle glaucoma (POAG). MATERIAL AND METHODS: A case-control study including 90 eyes of 90 patients who needed antiglaucomatous surgery in the course of POAG (glaucoma group, n = 50) and from patients who were operated of nonpathologic cataracts (cataract group, n = 40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) test and total antioxidant status in the aqueous humor samples of both groups were determined. Statistical analyses were carried out in relation to MDA-TBARS and total antioxidant status and their correlations with glaucoma risk factors. RESULTS: Significantly higher MDA-TBARS were detected in the POAG with respect to the comparative group of cataract subjects (P < 0.001). Antioxidant activity was significantly lower in the POAG than in the cataract group (P < 0.001). CONCLUSIONS: Aqueous humor samples may be used for determining oxidative and antioxidant status in pathologic processes. Glaucomatous eyes had a significant increase in oxidative status and decreased antioxidant activity in the aqueous humor than the cataract eyes. Oxidative stress may play a pathogenical role in the POAG.
Dr. V. Zanon-Moreno, Ophthalmologic Research Unit Santiago Grisolia, Dr Peset Universitary Hospital, Valencia, Spain. Zanon_vicmor@gva.es
Classification:
3.7 Biochemistry (Part of: 3 Laboratory methods)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)
