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Abstract #21813 Published in IGR 10-3
Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph
Nagai-Kusuhara A; Nakamura M; Kanamori A; Nakanishi Y; Kusuhara S; Negi AEye 2008; 22: 1154-1160
PURPOSE: To test whether Heidelberg Retina Tomograph (HRT) is applicable to assess the optic nerve head (ONH) configuration of the atrophic phase of non-glaucomatous optic neuropathy when a default set of the reference plane is used. METHODS: Ten eyes with non-arteritic anterior ischaemic optic neuropathy (NAION), 17 eyes with Leber's hereditary optic neuropathy (LHON), 40 eyes with compressive optic neuropathy (CON) owing to chiasmal tumour, and 241 eyes of control individuals were examined with HRT using the default reference plane. The global values of HRT parameters were evaluated among the groups of patients and controls. The sectoral measurements of the eyes with LHON and CON were compared with controls. To eliminate the influence of disc size and age on HRT measurements, eyes with disc area- and age-matched normal controls were used for comparison with eyes with NAION and LHON. RESULTS: Cup parameters in eyes with NAION were similar to those in controls. The retinal nerve fibre layer (RNFL) thickness was significantly thinner in eyes with NAION than that of controls. The eyes with LHON had significantly larger cup parameters, smaller rim volume, and thinner mean RNFL thickness than controls. Eyes with CON had significantly larger rim area and smaller cup parameters but similar RNFL thickness compared with controls. CONCLUSIONS: When the default reference plane is used, HRT can measure the ONH configuration in eyes with NAION and LHON as expected. However, caution must be made to interpret the parameters obtained from the eyes with CON.
Dr. A. Nagai-Kusuhara, Division of Ophthalmology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan
Classification:
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy