advertisement
Abstract #21831 Published in IGR 10-3
Morpho-functional follow-up of the optic nerve in treated ocular hypertension: Disc morphometry and steady-state pattern electroretinogram
Salgarello T; Falsini B; Stifano G; Montrone L; Iarossi G; Balestrazzi E; Colotto ACurrent Eye Research 2008; 33: 709-721
PURPOSE: To examine longitudinally optic disc structure and inner retinal function in treated ocular hypertension (OHT). MATERIALS AND METHODS: A morphometric (Heidelberg Retina Tomograph, HRT) and functional (steady-state pattern electroretinogram, PERG) evaluation of 27 OHT patients treated with topical β-blockers and/or prostaglandin analogues and prospectively followed over a 24 ± 6 month period. RESULTS: Compared with baseline, mean final PERG amplitude tended to increase (p < 0.01), while HRT was stable. Individual PERG amplitude increase was large (≥ 100%) in some patients (5/27), and unexplained by clinical parameters at baseline. CONCLUSIONS: In treated OHT, functional responses may improve while disc structure remains stable. The findings suggest that OHT-associated inner retinal dysfunction is at least in part reversible with therapeutic intraocular pressure control.
Dr. T. Salgarello, Institute of Ophthalmology, Catholic University of Sacred Heart, Rome, Italy. Tommaso.salgarello@rm.unicatt.it
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
6.9.1.1 Confocal Scanning Laser Ophthalmoscopy (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.1 Laser scanning)